Odomzo 200mg (sonidegib) is an oral medication used to treat a type of skin cancer called basal cell carcinoma. Odomzo 200mg (sonidegib) is an inhibitor of the hedgehog biological signaling pathway, a pathway that promotes the growth of both normal and cancer cells.
Odomzo 200mg (sonidegib) binds to and inhibits smoothened, a protein involved in hedgehog signaling. Inhibiting smoothened disrupts cell signaling and growth of cancer cells.
How Odomzo 200mg is Given
Odomzo 200mg (sonidegib) is a capsule, taken by mouth, once daily, taken on an empty stomach, at least 1 hour before or 2 hours after a meal.
Take sonidegib exactly as prescribed.
Swallow sonidegib whole. Do not crush, dissolve or open capsules.
Do not change your dose or stop sonidegib unless your health care provider tells you to.
If you miss a dose, do not make up; resume dosing with the next scheduled dose.
Do not take more than 1 dose of sonidegib at one time. Call your health care provider right away if you take too much.
The amount of sonidegib that you will receive depends on many factors, your general health or other health problems, and the type of cancer or condition being treated. Your doctor will determine your dose and schedule.
Side Effects Odomzo 200mg
Important things to remember about the side effects of sonidegib:
Most people do not experience all of the side effects listed.
Some side effects are predictable in terms of their onset and duration.
There are many options to help minimize or prevent side effects.
There is no relationship between the presence or severity of side effects and the effectiveness of the medication.
The following side effects are common (occurring in greater than 30%) for patients taking sonidegib:
Increased serum creatinine (reflects kidney function)
Increased serum creatine kinase (CK) (reflects muscle damage)
Hyperglycemia (high sugar in the blood)
High lipase (enzyme from the pancreas)
These side effects are less common side effects (occurring in about 10-29%) of patients receiving sonidegib:
Lymphocytopenia (lymphocytes are on type of blood cell-lymphocytopenia is low lymphocytes)
Lack of appetite
Increased liver enzymes
High amylase (enzyme produced by the pancreas)
Before starting sonidegib treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
Do not receive any kind of immunization or vaccination without your doctor’s approval while taking sonidegib.
The use of sonidegib during pregnancy may cause birth defects or death of the unborn baby.
Females will need to have a pregnancy test to show that they are NOT pregnant before starting this drug.
Effective contraception is required for females during treatment and for at least 20 months after completion of treatment.
Male patients need to use condoms with a female partner during treatment with sonidegib and for at least 8 months after the last dose, even following a vasectomy.
Male patients should not donate sperm during sonidegib treatment and for at least 8 months after the last dose.
Discuss with your doctor when you may safely become pregnant or conceive a child after therapy.
Do not breast feed while taking sonidegib and for 20 months after the last dose of sonidegib.we have spinraza in stock.